OperaV1, Main, Exploration, bibRecord, 000787

Music exposure induced prolongation of cardiac allograft survival and generated regulatory CD4⁺ cells in mice.

Identifieur interne : 000787 ( Main/Exploration ); précédent : 000786; suivant : 000788

Music exposure induced prolongation of cardiac allograft survival and generated regulatory CD4⁺ cells in mice.

Auteurs : M. Uchiyama [Japon] ; X. Jin ; Q. Zhang ; A. Amano ; T. Watanabe ; M. Niimi

Source :

Transplantation proceedings ; 2012.

RBID : pubmed:22564629

English descriptors

KwdEn :
- Acoustic Stimulation, Adoptive Transfer, Animals, Cell Proliferation, Cytokines (metabolism), Flow Cytometry, Forkhead Transcription Factors (metabolism), Graft Rejection (immunology), Graft Rejection (prevention & control), Graft Survival, Heart Transplantation (immunology), Histocompatibility, Interleukin-2 Receptor alpha Subunit (metabolism), Lymphocyte Activation, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred CBA, Music, Skin Transplantation (immunology), T-Lymphocytes, Regulatory (immunology), T-Lymphocytes, Regulatory (transplantation), Time Factors, Tympanic Membrane Perforation (immunology), Tympanic Membrane Perforation (physiopathology).
MESH :
- chemical , metabolism : Cytokines, Forkhead Transcription Factors, Interleukin-2 Receptor alpha Subunit.
- immunology : Graft Rejection, Heart Transplantation, Skin Transplantation, T-Lymphocytes, Regulatory, Tympanic Membrane Perforation.
- physiopathology : Tympanic Membrane Perforation.
- prevention & control : Graft Rejection.
- transplantation : T-Lymphocytes, Regulatory.
- Acoustic Stimulation, Adoptive Transfer, Animals, Cell Proliferation, Flow Cytometry, Graft Survival, Histocompatibility, Lymphocyte Activation, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred CBA, Music, Time Factors.

Abstract

In clinical practice, music has been used to decrease stress, heart rate, and blood pressure and to provide a distraction from disease symptoms. We investigated sound effects on alloimmune responses in murine heart transplantation. Naïve and eardrum-ruptured CBA/N (CBA, H2(K)) underwent transplantation of a C57BL/6 (B6, H2(b)) heart and were exposed to 1 of 3 types of music-opera (La Traviata), classical (Mozart), and New Age (Enya)-or 1 of 6 different single sound frequencies for 7 days. An adoptive transfer study was performed to determine whether regulatory cells were generated in allograft recipients. Cell-proliferation, cytokine, and flow cytometry assessments were also performed. CBA recipients of a B6 graft exposed to opera and classical music had significantly prolonged allograft survival (median survival times [MSTs], 26.5 and 20 days, respectively), whereas those exposed to 6 single sound frequencies and New Age did not (MSTs, 7, 8, 9, 8, 8, 8, and 11 days, respectively). Untreated and eardrum-ruptured CBA rejected B6 grafts acutely (MSTs, 7 and 8.5 days, respectively). Adoptive transfer of whole splenocytes, CD4(+) cells, and CD4(+)CD25(+) cells from opera-exposed primary recipients resulted in significantly prolonged allograft survival in naive secondary recipients (MSTs, 36, 68, and >50 days, respectively). Cell-proliferation, interleukin (IL)-2 and interferon-γ were suppressed in opera-exposed mice, whereas IL-4 and IL-10 from opera-exposed recipients were up-regulated. Flow cytometry studies showed an increased CD4(+)CD25(+)Foxp3(+) cell population in splenocytes from opera-exposed mice. In conclusion, exposure to some types of music may induce prolonged survival of fully allogeneic cardiac allografts and generate CD4(+)CD25(+)Foxp3(+) regulatory cells.

DOI: 10.1016/j.transproceed.2012.02.008
PubMed: 22564629

Affiliations:

Japon
Tokyo

Le document en format XML

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<author><name sortKey="Zhang, Q" sort="Zhang, Q" uniqKey="Zhang Q" first="Q" last="Zhang">Q. Zhang</name>
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<author><name sortKey="Amano, A" sort="Amano, A" uniqKey="Amano A" first="A" last="Amano">A. Amano</name>
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<series><title level="j">Transplantation proceedings</title>
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<term>Adoptive Transfer</term>
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<term>Cell Proliferation</term>
<term>Cytokines (metabolism)</term>
<term>Flow Cytometry</term>
<term>Forkhead Transcription Factors (metabolism)</term>
<term>Graft Rejection (immunology)</term>
<term>Graft Rejection (prevention & control)</term>
<term>Graft Survival</term>
<term>Heart Transplantation (immunology)</term>
<term>Histocompatibility</term>
<term>Interleukin-2 Receptor alpha Subunit (metabolism)</term>
<term>Lymphocyte Activation</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Inbred CBA</term>
<term>Music</term>
<term>Skin Transplantation (immunology)</term>
<term>T-Lymphocytes, Regulatory (immunology)</term>
<term>T-Lymphocytes, Regulatory (transplantation)</term>
<term>Time Factors</term>
<term>Tympanic Membrane Perforation (immunology)</term>
<term>Tympanic Membrane Perforation (physiopathology)</term>
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<term>Forkhead Transcription Factors</term>
<term>Interleukin-2 Receptor alpha Subunit</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Graft Rejection</term>
<term>Heart Transplantation</term>
<term>Skin Transplantation</term>
<term>T-Lymphocytes, Regulatory</term>
<term>Tympanic Membrane Perforation</term>
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<keywords scheme="MESH" xml:lang="en"><term>Acoustic Stimulation</term>
<term>Adoptive Transfer</term>
<term>Animals</term>
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<term>Lymphocyte Activation</term>
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<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Inbred CBA</term>
<term>Music</term>
<term>Time Factors</term>
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<front><div type="abstract" xml:lang="en">In clinical practice, music has been used to decrease stress, heart rate, and blood pressure and to provide a distraction from disease symptoms. We investigated sound effects on alloimmune responses in murine heart transplantation. Naïve and eardrum-ruptured CBA/N (CBA, H2(K)) underwent transplantation of a C57BL/6 (B6, H2(b)) heart and were exposed to 1 of 3 types of music-opera (La Traviata), classical (Mozart), and New Age (Enya)-or 1 of 6 different single sound frequencies for 7 days. An adoptive transfer study was performed to determine whether regulatory cells were generated in allograft recipients. Cell-proliferation, cytokine, and flow cytometry assessments were also performed. CBA recipients of a B6 graft exposed to opera and classical music had significantly prolonged allograft survival (median survival times [MSTs], 26.5 and 20 days, respectively), whereas those exposed to 6 single sound frequencies and New Age did not (MSTs, 7, 8, 9, 8, 8, 8, and 11 days, respectively). Untreated and eardrum-ruptured CBA rejected B6 grafts acutely (MSTs, 7 and 8.5 days, respectively). Adoptive transfer of whole splenocytes, CD4(+) cells, and CD4(+)CD25(+) cells from opera-exposed primary recipients resulted in significantly prolonged allograft survival in naive secondary recipients (MSTs, 36, 68, and >50 days, respectively). Cell-proliferation, interleukin (IL)-2 and interferon-γ were suppressed in opera-exposed mice, whereas IL-4 and IL-10 from opera-exposed recipients were up-regulated. Flow cytometry studies showed an increased CD4(+)CD25(+)Foxp3(+) cell population in splenocytes from opera-exposed mice. In conclusion, exposure to some types of music may induce prolonged survival of fully allogeneic cardiac allografts and generate CD4(+)CD25(+)Foxp3(+) regulatory cells.</div>
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<name sortKey="Zhang, Q" sort="Zhang, Q" uniqKey="Zhang Q" first="Q" last="Zhang">Q. Zhang</name>
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<country name="Japon"><noRegion><name sortKey="Uchiyama, M" sort="Uchiyama, M" uniqKey="Uchiyama M" first="M" last="Uchiyama">M. Uchiyama</name>
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Music exposure induced prolongation of cardiac allograft survival and generated regulatory CD4⁺ cells in mice.

Music exposure induced prolongation of cardiac allograft survival and generated regulatory CD4⁺ cells in mice.

Source :

English descriptors

Abstract

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